The Carroll Lab is interested in understanding how Estrogen Receptor (ER) causes gene transcription and how this contributes to breast cancer progression. We are also interested in understanding how breast cancer therapies work and what happens if they fail. We explore this using molecular, genomic and proteomic approaches, with the goal of identifying the critical determinants of tumour progression so that we can develop novel therapies that specifically target them.
When we read the pioneering research about the role of prenatal sex steroid hormones in autism, we started a collaboration with the Autism Research Centre. We have been collaborating with the ARC for a number of years, with a focus on understanding the role of hormones, such as testosterone and estrogen on neurons derived from autistic people and not autistic people and to explore the potential link between autism and cancer rates.